URAP

Amanda Win Soe

Biogenesis of Heart Rhythm

The sinoatrial node is a small cluster of myocytes that is located at the junction of the upper wall of the right atrium and the superior vena cava. These cells have specialized pacemaker properties that can spontaneously generate electrical impulses for the contraction of the heart. Using mouse models to study changes in the development and function of these cells through genetic, molecular and electrophysiological analysis, our lab aims to learn more about what differentiates pacemaker cells of the sinoatrial node from other myocytes and their potential roles in the causes of arrhythmias. This summer, I will be working with genetic analysis of different genotypic profiles of mice, surgical implantation of transmitters and analysis of EKGs, variabilities of heart rates and arrhythmias. Additionally, I will be using these methods to learn more about the genotypic, functional and physiological differences of heart rhythm that are induced by pregnancy in mice.

Message to Sponsor

I would like to genuinely thank you for your support in allowing me this opportunity to work on what I would love to as a career this early on in my educational years and do so under the guidance of experts. As someone who learns so much every minute I am in the lab, being able to work full time during the summer means experience and exposure about cardiac function and physiology that I could not have otherwise. Thank you so much for your support.
  • Major: Molecular and Cell Biology
  • Mentor: Vasanth Vedantham, Cardiology at UCSF