URAP

Carmel Malvar

Dengue Virus NS1 protein

This summer, I will be working on investigating the structure and molecular determinants of the Dengue Virus NS1 protein. Dengue Virus affects hundreds of millions of patients annually and can lead to symptoms such as hemorrhagic fever or shock syndrome. My work will be building on our findings in lab from the past year regarding key amino acid sites on NS1’s role in compromising endothelial permeability and I am hoping to create new mutant proteins to help further our investigation.

Message to Sponsor

I am very thankful for the wonderful generosity of the Chandra Fund because this support has allowed me to not only work on generating these new constructs but also, to optimize the existing protocols we have in our lab for generating our final protein product. We've made several key changes to our protocols that have maximized our efficiency and yield and will be extremely useful as I continue on with my project in the upcoming school year.
  • Major: Microbial Biology and Public Health
  • Mentor: Eva Harris, Public Health