Acquisition of Endothermy May Cause the Loss of Cardiac Regenerative Potential
The summer research project will help further my understanding on factors that will affect the regenerative process of cardiomyocyte cells that would be significant in regenerative heart treatment. The project will enable me to learn how to conduct mammalian cell cultures and examine an engineered mouse strain in which the chemogenetic activation of hypothalamic thermoregulatory neurons by small chemicals, potentially induces drastic reductions of body temperature and energy metabolism like the state in torpor or hibernation. In particular, I will examine whether lowering body temperature could retain cardiac regenerative potential using this mouse model. If the analysis is correct, this would indicate the first direct evidence for the causality between the increase of thermogenesis and the loss of heart regenerative capacity.
Message to Sponsor
- Major: Molecular and Cell Biology
- Mentor: Guo Huang, UCSF