Using the Endogenous Tagging of B-catenin in Zebrafish to Study WNT Signaling Pathways Implicated in Colon Cancer
WNT signaling pathways are pattern-forming, cell signaling cascades that are significant drivers in embryogenesis, cell development, homeostasis, and tumorigenesis. They involve a major component, a protein called B-catenin, which is implicated downstream in colorectal cancer cell lines. This summer, I will be utilizing genome editing tools and live-organism imaging to study the endogenous form of B-catenin in canonical WNT signaling, by inserting fluorescent proteins into the gene, with the intention to quantify and further understand the protein’s roles in a live organism.
Message to Sponsor
- Major: Molecular & Cell Biology
- Mentor: Ian Swinburne and Cyna Shirazinejad/ Molecular & Cell Biology