Dengue Virus Pathogenesis in a Mouse Model
Dengue virus is one of the most increasingly concerning mosquito-borne diseases that infects almost 400 million individuals annually at tremendous cost to not just afflicted patients but entire healthcare infrastructure systems. My research this coming Summer is a continuation of my work in the Harris lab since Fall 2017 where I have been investigating the role of dengue virus non-structural protein (NS1) on the pathogenesis of the disease. Specifically, my research scope focuses on if NS1-induced vascular leak (one of the main clinical indicators of disease) can be inhibited by monoclonal antibodies or anti-sera targeting NS1 in a mouse model. The hope is that findings from this research initiative will provide preliminary data with the potential for future implications on the development of protective vaccines and therapeutic treatments.
Message to Sponsor
- Major: Public Health
- Mentor: Dr. Eva Harris